Ciprofloxacin and probiotic Escherichia coli Nissle add-on treatment in active ulcerative colitis: A double-blind randomized placebo controlled clinical trial

  • Petersen A
  • Mirsepasi H
  • Halkjaer S
 et al. 
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Background and aim: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The probiotic bacterium Escherichia coli Nissle 1917 (EcN) has been used to maintain and induce clinical remission in UC. Our aim was to test the effect of Ciprofloxacin and/or orally administered EcN as add-on to conventional therapies in patients with active UC. Patients and methods: Our single center double-blinded randomized placebo controlled study included patients with a Colitis Activity Index (CAI) score of at least 6. Patients were randomized to Ciprofloxacin or placebo for 1. week followed by EcN or placebo for 7. weeks. All 4 treatments were given as add-on treatments. Results: One hundred subjects with active UC were recruited. In the per-protocol analysis we, surprisingly, found that in the group receiving placebo/EcN fewer patients, 54%, reached remission compared to the group receiving placebo/placebo, 89%, p.

Author-supplied keywords

  • Ciprofloxacin
  • E. coli Nissle
  • Escherichia coli
  • Ulcerative colitis

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  • Andreas Munk Petersen

  • Hengameh Mirsepasi

  • Sofie Ingdam Halkjaer

  • Esben Munk Mortensen

  • Inge Nordgaard-Lassen

  • Karen Angeliki Krogfelt

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