Circulating tumor cells, disease progression, and survival in metastatic breast cancer

  • CRISTOFANILLI M
  • BUDD G
  • ELLIS M
 et al. 
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Abstract

BACKGROUND We tested the hypothesis that the level of circulating tumor cells can predict survival in metastatic breast cancer. METHODS In a prospective, multicenter study, we tested 177 patients with measurable metastatic breast cancer for levels of circulating tumor cells both before the patients were to start a new line oftreatment and at the first follow-up visit. The progression ofthe disease or the response to treatment was determined with the use of standard imaging studies at the participating centers. RESULTS Outcomes were assessed according to levels of circulating tumor cells at baseline, before the patients started a new treatment for metastatic disease. Patients in a training set with levels of circulating tumor cells equal to or higher than 5 per 7.5 ml of whole blood, as compared with the group with fewer than 5 circulating tumor cells per 7.5 ml, had a shorter median progression-free survival (2.7 months vs. 7.0 months, P18 months, P18 months; P

Author-supplied keywords

  • Advanced stage
  • Breast cancer
  • Cancer du sein
  • Cellule tumorale
  • Cáncer del pecho
  • Célula tumoral
  • Disease
  • Enfermedad
  • Estadio avanzado
  • Glande mammaire
  • Glande mammaire pathologie
  • Glándula mamaria
  • Glándula mamaria patología
  • Maladie
  • Malignant tumor
  • Mammary gland
  • Mammary gland diseases
  • Medicina
  • Medicine
  • Metastasis
  • Metastatic
  • Metastásico
  • Metástasis
  • Médecine
  • Métastase
  • Métastatique
  • Progresión carcinogénesis
  • Progression carcinogenèse
  • Sobrevivencia
  • Stade avancé
  • Survie
  • Survival
  • Tumeur maligne
  • Tumor cell
  • Tumor maligno
  • Tumor progression

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Authors

  • Massimo CRISTOFANILLI

  • G. Thomas BUDD

  • Matthew J. ELLIS

  • Alison STOPECK

  • Jeri MATERA

  • M. Craig MILLER

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