The crude extract of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication. Bioassay-guided fractionation led to the isolation of the known compound mellein as the active component of the extract. Also isolated were circumdatin F and a new alkaloid, circumdatin G. The structure of circumdatin G was determined by spectroscopic analysis.
CITATION STYLE
Dai, J. R., Carté, B. K., Sidebottom, P. J., Yew, A. L. S., Ng, S. B., Huang, Y., & Butler, M. S. (2001). Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus. Journal of Natural Products, 64(1), 125–126. https://doi.org/10.1021/np000381u
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