A clinical and epidemiological review of non-toxigenic Clostridium difficile.

  • Natarajan M
  • Walk S
  • Young V
 et al. 
  • 2

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Clostridium difficile is a significant nosocomial threat to human health and is the most commonly identified cause of antibiotic-associated diarrhea. The development of C. difficile colitis requires production of toxins A and/or B, but some strains do not express these proteins. These non-toxigenic C. difficile (NTCD) have garnered attention for their capacity to colonize humans and potentially reduce the risk for symptomatic colitis caused by toxigenic strains. Isolates of NTCD have been obtained from the environment as well as from animal and human sources. Studies in a hamster CDI model have demonstrated a protective effect of NTCD against toxigenic infection. The extent to which this protective effect of NTCD occurs in humans remains to be defined. Evidence for a therapeutic or preventive role for NTCD is limited but clinical prophylaxis studies are ongoing. NTCD potentially represents an exciting new tool in preventing CDI and its recurrences.

Author-supplied keywords

  • Animal
  • Animals
  • Bacterial Toxins
  • Clostridium Infections
  • Clostridium difficile
  • Cricetinae
  • Cross Infection
  • Diarrhea
  • Disease Models
  • Enterotoxins
  • Humans
  • Protective Agents
  • Species Specificity
  • classification
  • drug therapy
  • epidemiology
  • microbiology
  • pathogenicity
  • prevention & control
  • therapeutic use
  • toxicity

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • M Natarajan

  • ST Walk

  • VB Young

  • DM Aronoff

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free