Clinical and immunological characteristics of type 1 diabetes mellitus in a northwestern Colombian population.

  • Tobon G
  • Arango A
  • Abad V
 et al. 
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We underwent a project aimed to define the clinical and immunological characteristics of type 1 diabetes (T1D) in a Colombian population. This was a multicenter and cross-sectional study. Patients were systematically interviewed and their medical records reviewed, using a questionnaire that sought information about demographic, clinical and immunological characteristics. Glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A) and insulin antibodies (IAA) were examined by radioimmunoassay. There were 107 patients with T1D. Male:female ratio was 1:1. Half of the patients developed diabetes ketoacidosis at onset. GADA, IA-2A, and IAA were detected in 45%, 40%, and 69% of the cases, respectively. GADA positive patients were older and had a less duration of disease than patients without these autoantibodies (p

Author-supplied keywords

  • Adult
  • Age of Onset
  • Autoantibodies
  • Colombia
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 1
  • Diabetic Ketoacidosis
  • Female
  • Glutamate Decarboxylase
  • Humans
  • Insulin Antibodies
  • Male
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatases
  • blood
  • complications
  • etiology
  • immunology

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  • G J Tobon

  • A Arango

  • V Abad

  • J Garcia

  • H Cuervo

  • A Velasquez

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