Clinical and immunological characteristics of type 1 diabetes mellitus in a northwestern Colombian population

  • Tobon G
  • Arango A
  • Abad V
 et al. 
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Abstract

We underwent a project aimed to define the clinical and immunological characteristics of type 1 diabetes (T1D) in a Colombian population. This was a multicenter and cross-sectional study. Patients were systematically interviewed and their medical records reviewed, using a questionnaire that sought information about demographic, clinical and immunological characteristics. Glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A) and insulin antibodies (IAA) were examined by radioimmunoassay. There were 107 patients with T1D. Male:female ratio was 1:1. Half of the patients developed diabetes ketoacidosis at onset. GADA, IA-2A, and IAA were detected in 45%, 40%, and 69% of the cases, respectively. GADA positive patients were older and had a less duration of disease than patients without these autoantibodies (p

Author-supplied keywords

  • Colombia
  • GADA
  • IA-2A
  • IAA
  • Type 1 diabetes

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Authors

  • G.J. Tobon

  • A. Arango

  • V. Abad

  • J. García

  • H. Cuervo

  • A. Velásquez

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