Clinical profile and follow-up of paediatric neurocysticercosis cases: A study from Eastern India

  • Bhattacharjee S
  • Biswas P
  • Mondal T
 et al. 
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Abstract

Introduction: Neurocysticercosis is the most common parasitic central nervous infection worldwide. Our present study attempts to evaluate the clinical profiles, treatment outcome and 2 years of mean follow-up results of 38 paediatric neurocysticercosis patients of an Eastern Indian hospital. Methods: Diagnosis was mainly based on clinical features, computed tomography (CT) / Magnetic resonance imaging (MRI) scan and exclusion of other causes. Symptomatic, active cyst patients were treated with albendazole for 28 days, steroids and anticonvulsants. Results: Mean age of presentation was 8.47+3.19 yrs. Patients presented with generalized seizures in 55.3%, focal seizures, in 31.6%, headache + vomiting in 63.2%, focal neurodeficit in 10.5% and combination of symptoms in 60.5% cases. Contrast CT brain showed solitary lesion in 27 (71.1%) and multiple in the rest. Among the solitary lesions, parietal lobe was involved in 74.1%, frontal lobe in 14.8%. At presentation, lesions were transitional (ring enhancing) in 58.2%, inactive in 20%, mixed in 14.6% and active in the rest. After 2 years of mean follow-up, seizure persisted in 9, headache in 8 cases with permanent neurodeficit in none. 44.7% lesions calcified, 31.6% disappeared, 10.5% regressed and the rest persisted. Conclusion: Solitary ring enhancing lesions (transitional stage) involving the parietal lobe was the commonest CT picture at presentation. Generalized seizure was the commonest presentation. Calcification of the lesion was the commonest mode of healing followed by the disappearance of the lesions. No particular risk factor was found to be prognostically significant (p value>0.05).

Author-supplied keywords

  • follow up neurocysticercosis India health care org

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Authors

  • S Bhattacharjee

  • P Biswas

  • T Mondal

  • D S P Saha

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