Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States foodnet multicenter retrospective cohort study

  • Crump J
  • Kretsinger K
  • Gay K
 et al. 
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Patients with typhoid fever due to Salmonella enterica serotype Typhi strains for which fluoroquinolones MICs are elevated yet that are classified as susceptible by the current interpretive criteria of the Clinical and Laboratory Standards Institute may not respond adequately to fluoroquinolone therapy. Patients from seven U.S. states with invasive Salmonella serotype Typhi infection between 1999 and 2002 were enrolled in a multicenter retrospective cohort study. Patients infected with Salmonella serotype Typhi isolates with ciprofloxacin MICs of 0.12 to 1 microg/ml (decreased ciprofloxacin susceptibility but not resistant to ciprofloxacin [DCS]) were compared with patients infected with isolates with ciprofloxacin MICs

Author-supplied keywords

  • *Drug Resistance, Bacterial
  • Adolescent
  • Adult
  • Anti-Bacterial Agents/*pharmacology/therapeutic us
  • Child
  • Child, Preschool
  • Ciprofloxacin/pharmacology/therapeutic use
  • Cohort Studies
  • Female
  • Fluoroquinolones/*pharmacology/therapeutic use
  • Foodborne Diseases/epidemiology
  • Hospitalization
  • Humans
  • Infant
  • Male
  • Microbial Sensitivity Tests/standards
  • Middle Aged
  • Population Surveillance
  • Retrospective Studies
  • Salmonella typhi/*drug effects
  • Treatment Outcome
  • Typhoid Fever/*drug therapy/microbiology
  • United States

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  • J A Crump

  • K Kretsinger

  • K Gay

  • R M Hoekstra

  • D J Vugia

  • S Hurd

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