Clonal association of Staphylococcus aureus causing bullous impetigo and the emergence of new methicillin-resistant clonal groups in Kansai district in Japan

  • Yamaguchi T
  • Yokota Y
  • Terajima J
 et al. 
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Abstract

A molecular epidemiological analysis was performed to reveal the clonal association of Staphylococcus aureus strains isolated from patients with bullous impetigo. Pulsed-field gel electrophoresis with cluster analysis, genetic and phenotypic characterizations, and antimicrobial susceptibility profiling of 88 S. aureus strains isolated from outpatients at 4 hospitals in the Kansai district in Japan were undertaken. Three distinct clonal groups were identified: 2 of them carried the exfoliative toxin (ET) A gene (eta), and the other carried the ETB gene (etb). The former groups represent 2 eta-positive clonal groups that have not been described previously. All the strains in the more dominant eta-positive clonal group and some of the strains in the etb-positive clonal group were methicillin-resistant S. aureus (MRSA) showing borderline-to-moderate resistance to beta-lactams. These MRSA strains appear to be emerging clonal groups that have not been considered in previous epidemiological studies of ET-producing S. aureus in Japan and thus pose a significant threat for future treatment of patients with bullous impetigo and/or staphylococcal scalded-skin syndrome

Author-supplied keywords

  • ARTICLE
  • ASSOCIATION
  • AUREUS
  • AUREUS STRAINS
  • Bacteriology
  • Blister
  • Cluster Analysis
  • DNA
  • DNA,Bacterial
  • EMERGENCE
  • Electrophoresis
  • Hospitals
  • Humans
  • Impetigo
  • Japan
  • METHICILLIN-RESISTANT
  • MRSA
  • Methicillin
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Outpatients
  • Patients
  • Penicillins
  • Polymorphism,Restriction Fragment Length
  • RESISTANCE
  • Research
  • Research Support
  • STAPHYLOCOCCUS-AUREUS
  • STRAINS
  • SUSCEPTIBILITY
  • Staphylococcal Scalded Skin Syndrome
  • Staphylococcus
  • Staphylococcus aureus
  • Syndrome
  • Universities
  • analysis
  • beta-Lactams
  • drug effects
  • epidemiology
  • genetics
  • pharmacology
  • strain
  • study
  • treatment

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Authors

  • T Yamaguchi

  • Y Yokota

  • J Terajima

  • T Hayashi

  • M Aepfelbacher

  • M Ohara

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