Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

  • Habas R
  • Dawid I
  • He X
  • 184


    Mendeley users who have this article in their library.
  • 414


    Citations of this article.


Wnt/Frizzled (Fz) signaling controls cell polarity/movements during vertebrate gastrulation via incompletely defined mechanisms. We demonstrated previously that Wnt/Fz activation of Rho, a GTPase and regulator of cytoskeletal architecture, is essential for vertebrate gastrulation. Here we report that in mammalian cells and Xenopus embryos, Wnt/Fz signaling coactivates Rho and Rac, another GTPase and distinct regulator of cytoskeletal architecture. Wnt/Fz activation of Rac is independent of Rho and mediates Wnt/Fz activation of Jun N-terminal kinase (JNK). Dishevelled (Dvl), a cytoplasmic protein downstream of Fz, forms a Wnt-induced complex with Rac independent of the Wnt-induced Dvl-Rho complex. Depletion or inhibition of Rac function perturbs Xenopus gastrulation without affecting Wnt/Fz activation of the Rho or beta-catenin pathway. We propose that parallel activation of Rac and Rho pathways by Wnt/Fz signaling is required for cell polarity and movements during vertebrate gastrulation.

Author-supplied keywords

  • Frizzled
  • Gastrulation
  • Rac
  • Rho
  • Vertebrates
  • Wnt

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Raymond Habas

  • Igor B. Dawid

  • Xi He

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free