Coat variation in the domestic dog is governed by variants in three genes

  • Cadieu E
  • Neff M
  • Quignon P
 et al. 
  • 319

    Readers

    Mendeley users who have this article in their library.
  • 164

    Citations

    Citations of this article.

Abstract

Coat color and type are essential characteristics of domestic dog breeds. Although the genetic basis of coat color has been well characterized, relatively little is known about the genes influencing coat growth pattern, length, and curl. We performed genome-wide association studies of more than 1000 dogs from 80 domestic breeds to identify genes associated with canine fur phenotypes. Taking advantage of both inter- and intrabreed variability, we identified distinct mutations in three genes, RSPO2, FGF5, and KRT71 (encoding R-spondin-2, fibroblast growth factor-5, and keratin-71, respectively), that together account for most coat phenotypes in purebred dogs in the United States. Thus, an array of varied and seemingly complex phenotypes can be reduced to the combinatorial effects of only a few genes.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Edouard Cadieu

  • Mark W. Neff

  • Pascale Quignon

  • Kari Walsh

  • Kevin Chase

  • Heidi G. Parker

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free