Cofactor biosynthesis: a mechanistic perspective

  • Begley T
  • Kinsland C
  • Taylor S
 et al. 
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Abstract

A review, with 217 refs. The chem. of the cofactors has provided a fertile area of overlap between org. chem. and biochem., and the org. chem. of the cofactors is now a thoroughly studied area. In contrast, the chem. of cofactor biosynthesis is still relatively underdeveloped. In this review the biosynthesis of NAD, riboflavin, folate, molybdopterin, thiamin, biotin, lipoic acid, pantothenic acid, CoA, S-adenosylmethionine, pyridoxal phosphate, ubiquinone and menaquinone in E. coli will be described with a focus on unsolved mechanistic problems. [on SciFinder (R)]

Author-supplied keywords

  • Coenzymes
  • Escherichia cofactor biosynthesis review
  • Escherichia coli (Escherichia coli cofactor biosyn
  • Ubiquinones Role: BSU (Biological study, unclassif
  • review cofactor biosynthesis mechanism

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Authors

  • Tadhg P Begley

  • Cynthia Kinsland

  • Sean Taylor

  • Manish Tandon

  • Robb Nicewonger

  • Min Wu

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