Cognitive behavior therapy in panic disorder and comorbid major depression

  • W. R
  • S. T
  • C. A
 et al. 
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Background: There is a lack of evidence about the effectiveness of cognitive behavior therapies (CBT) in settings of routine clinical care as well as in the treatment of panic and comorbid disorders. Methods: We investigated a group-oriented CBT approach for 80 patients with panic disorder including 35 patients with current comorbid major depression. Assessments took place 6 months before treatment, at the beginning and end of treatment, and 1 year later. Structured interviews and multiple clinical self-rating scales were used. Results: Panic patients with comorbid major depression showed higher anxiety-specific and nonspecific pathology. The most striking benefits were in reducing avoidance behavior, while improvements concerning catastrophic beliefs were smaller, but still significant. For most self-rating scale results, patients with and without comorbid depression improved to a comparable degree. However, the end-state functioning of patients with panic disorder and current comorbid depression at admission is significantly lower than for patients with panic disorder alone. Conclusions: The results point to the necessity to develop and improve treatment approaches for patients with comorbidity of panic disorder and current major depression. Copyright (C) 2000 S. Karger AG, Basel.

Author-supplied keywords

  • adult
  • antidepressant agent
  • anxiety
  • article
  • behavior therapy
  • benzodiazepine derivative
  • clinical trial
  • cognitive therapy
  • comorbidity
  • depression
  • female
  • human
  • major clinical study
  • male
  • mental health care
  • panic
  • tricyclic antidepressant agent

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  • Rief W.

  • Trenkamp S.

  • Auer C.

  • Fichter M.M.

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