Cognitive changes following subthalamic nucleus stimulation in two patients with Parkinson disease.

  • Moretti R
  • Torre P
  • Antonello R
 et al. 
  • 5


    Mendeley users who have this article in their library.
  • 25


    Citations of this article.


The limits of a drug therapy in severe forms of Parkinson disease have led to refining neurosurgery on the basal ganglia. Deep brain stimulation of the subthalamic nucleus has been recognized as one of the most promising techniques to decrease "off" motor symptoms and motor fluctuations, allowing a reduction of drug therapy and limiting side effects of the drugs. There is still open debate on the possible consequences of chronic subthalamic stimulation in other ways, apart from motor symptoms, of general cognitive performance. We examined and followed two patients with Parkinson disease for 9 mo. after surgery for deep stimulation, studying their cognitive performances. There is a general amelioration of cognitive performances, in particular as far as linguistic capabilities is concerned. We discuss the possible significance of these results, reminding strenuously that only two patients were involved, so the potential for generalization is seriously limited.

Author-supplied keywords

  • Aged
  • Attention
  • Electric Stimulation Therapy
  • Electrodes, Implanted
  • Follow-Up Studies
  • Humans
  • Male
  • Mental Recall
  • Middle Aged
  • Neuropsychological Tests
  • Parkinson Disease
  • Problem Solving
  • Reaction Time
  • Subthalamic Nucleus
  • Verbal Behavior
  • physiology
  • physiopathology
  • statistics & numerical data
  • therapy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Rita Moretti

  • Paola Torre

  • Rodolfo M Antonello

  • Livio Capus

  • Manuela Gioulis

  • Sandro Zambito Marsala

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free