Part of introduction: The lesions seen in patients with NMDs occur in utero during neuronal migration. The brain is broadly acknowledged to have considerable plasticity during its early development, and so it is conceivable that some reorganisation of cognitive ability may occur in patients who acquire lesions early in life. Thus a combination of functional neuroanatomy and neuropsychological assessment with NMD patients may provide a fruitful model for further exploring the 'Kennard effect', the phenomenon by which cognitive function is subserved by untypical neural substrates. In our discussion of the various forms of NMD we will further allude to this possibility.
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