Parkinson's disease (PD) is classically thought of as a movement
disorder characterized by tremor, rigidity and postural instability.
Nevertheless, there is growing recognition of prominent cognitive
impairment in PD and related disorders, which is responsible for
substantial disability in these patients. This review will focus on
cognitive impairment associated with Lewy body pathology, including PD
with dementia (PDD) and dementia with Lewy bodies (DLB). We will review
the epidemiology, clinical evaluation, underlying mechanisms and
treatment of cognitive impairment in these patients. Despite differences
between PDD and DLB, there is clinical, neuropathological and
radiological overlap between these disorders, supporting the view that
they represent a spectrum of disease. These observations suggest that
common targets for diagnosis and treatment of these disorders can be
identified. Copyright (c) 2008 S. Karger AG, Basel.
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