Combined snake venomics and venom gland transcriptomic analysis of Bothropoides pauloensis

  • Rodrigues R
  • Boldrini-França J
  • Fonseca F
 et al. 
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Abstract

Unraveling the repertoire of venom toxins of Bothropoides pauloensis was assessed by snake venomics and venom gland transcriptomic surveys. Both approaches yielded converging overall figures, pointing to metalloproteinases (~37%), PLA2s (26-32%), and vasoactive (bradykinin-potentiating) peptides (12-17%) as the major toxin classes. The high occurrence of SVMPs, PLA2molecules, vasoactive peptides, along with serine proteinases, explains the local and systemic effects observed in envenomations by B. pauloensis. Minor (

Author-supplied keywords

  • Bothropoides pauloensis
  • Mass spectrometry
  • Snake venomics
  • Venom gland transcriptome

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Authors

  • Renata S. Rodrigues

  • Johara Boldrini-França

  • Fernando P.P. Fonseca

  • Pilar de la Torre

  • Flávio Henrique-Silva

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