Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes

  • Hain T
  • Ghai R
  • Billion A
 et al. 
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Listeria monocytogenes is a food-borne pathogen that causes infections with a high-mortality rate and has served as an invaluable model for intracellular parasitism. Here, we report complete genome sequences for two L. monocytogenes strains belonging to serotype 4a (L99) and 4b (CLIP80459), and transcriptomes of representative strains from lineages I, II, and III, thereby permitting in-depth comparison of genome- and transcriptome -based data from three lineages of L. monocytogenes. Lineage III, represented by the 4a L99 genome is known to contain strains less virulent for humans. PMID: 22530965

Author-supplied keywords

  • Comparative genomics
  • Comparative transcriptomics
  • Flagella
  • Gene decay
  • Isogenic deletion mutants
  • Lineage
  • Listeria monocytogenes
  • Monocin
  • Murine infection
  • Prophage

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  • Torsten Hain

  • André Billion

  • Carsten T. Kuenne

  • Christiane Steinweg

  • Benjamin Izar

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