Comparative lesion sequencing provides insights into tumor evolution

  • Jones S
  • Chen W
  • Parmigiani G
 et al. 
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We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i) It takes approximately 17 years for a large benign tumor to evolve into an advanced cancer but

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  • S. Jones

  • W.-d. Chen

  • G. Parmigiani

  • F. Diehl

  • N. Beerenwinkel

  • T. Antal

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