Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures.

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Abstract

OBJECTIVE: To evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures. METHODS: Prospective randomized study. Total 125 children of all ages of either sex, for seizure episode (n-76) and various invasive and non-invasive procedures (n-49) received either intranasal midazolam (0.2 mg/Kg) or intravenous diazepam (0.3 mg/Kg). RESULTS. Mean time from arrival at hospital to starting treatment was significantly shorter in midazolam group compared to diazepam group [2.34+/-0.90; minute vs 4.61+/-1.08 minute p< 0.001]. Mean time to control seizures after arrival in hospital was significantly shorter in midazolam group compared to diazepam group [5.25+/-0.86 minute vs 6.51+/-1.06 minute p. CONCLUSION: Midazolam by the intranasal route provides safe and equally effective non-invasive method of sedation for procedures and seizures.

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Mittal, P., Manohar, R., & Rawat, A. K. (2006). Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures. Indian Journal of Pediatrics, 73(11), 975–978. https://doi.org/10.1007/bf02758299

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