Comparing adiposity profiles in three mouse models with altered GH signaling

  • Berryman D
  • List E
  • Coschigano K
 et al. 
  • 53

    Readers

    Mendeley users who have this article in their library.
  • 178

    Citations

    Citations of this article.

Abstract

Three mouse lines with altered growth hormone (GH) signaling were used to study GH's role in adiposity. Dwarf GH receptor knockout mice (GHR -/-) and bovine GH antagonist expressing mice (GHA) had an increased percent body fat with most of the excess fat mass accumulating in the subcutaneous region. Giant bovine GH expressing mice (bGH) had a reduced percent body fat. Only GHA mice consumed significantly more food per body weight. Serum leptin levels were significantly increased in GHA mice and decreased in bGH mice but unchanged in the GHR -/- mice. Interestingly, serum adiponectin levels were significantly increased in the GHR -/- and GHA lines but decreased in bGH mice. These data suggest that suppression or absence of GH action and enhanced GH action indeed have opposite metabolic effects in terms of adiposity. Interestingly, adiponectin levels were positively correlated with previously reported insulin sensitivity of these mice, but also positively correlated with adiposity, which is contrary to findings in other mouse models. Thus, adiponectin levels were negatively correlated with GH function suggesting a role for adiponectin in GH-induced insulin resistance. © 2004 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Adiponectin
  • Adiposity
  • Body composition
  • Bovine growth hormone transgenic
  • Growth hormone antagonist
  • Growth hormone receptor knockout
  • Leptin

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Darlene E. Berryman

  • Edward O. List

  • Karen T. Coschigano

  • Kevin Behar

  • Jason K. Kim

  • John J. Kopchick

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free