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Journal article

Comparing whole genomes using DNA microarrays

Gresham D, Dunham M, Botstein D ...see all

Nat Rev Genet, vol. 9, issue 4 (2008) pp. 291-302

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The rapid accumulation of complete genomic sequences offers the opportunity to carry out an analysis of inter- and intra-individual genome variation within a species on a routine basis. Sequencing whole genomes requires resources that are currently beyond those of a single laboratory and therefore it is not a practical approach for resequencing hundreds of individual genomes. DNA microarrays present an alternative way to study differences between closely related genomes. Advances in microarray-based approaches have enabled the main forms of genomic variation (amplifications, deletions, insertions, rearrangements and base-pair changes) to be detected using techniques that are readily performed in individual laboratories using simple experimental approaches.

Author-supplied keywords

  • Animals Chromosome Mapping Gene Dosage *Genetic Va

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  • D Gresham

  • M J Dunham

  • D Botstein

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