Comparison of closed loop vs. manual administration of propofol using the Bispectral index in cardiac surgery

  • Agarwal J
  • Puri G
  • Mathew P
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BACKGROUND: In recent years, electroencephalographic indices of anaesthetic depth have facilitated automated anaesthesia delivery systems. Such closed-loop control of anaesthesia has been described in various surgical settings in ASA I-II patients (1-4), but not in open heart surgery characterized by haemodynamic instability and higher risk of intra-operative awareness. Therefore, a newly developed closed-loop anaesthesia delivery system (CLADS) to regulate propofol infusion by the Bispectral index (BIS) was compared with manual control during open heart surgery. METHODS: Forty-four adult ASA II-III patients undergoing elective cardiac surgery under cardiopulmonary bypass were enrolled. The study participants were randomized to two groups: the CLADS group received propofol delivered by the CLADS, while in the manual group, propofol delivery was adjusted manually. The depth of anaesthesia was titrated to a target BIS of 50 in both the groups. RESULTS: During induction, the CLADS group required lower doses of propofol (P

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  • J. Agarwal

  • G. D. Puri

  • P. J. Mathew

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