Comparison of inspiratory and expiratory resistance and reactance in patients with asthma and chronic obstructive pulmonary disease

  • Paredi P
  • Goldman M
  • Alamen A
 et al. 
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BACKGROUND: The usual analysis of forced oscillometry measures respiratory resistance (Rrs) and reactance (Xrs) averaged over several tidal breaths (whole-breath analysis). Recent within-breath analyses have separated Rrs and Xrs into their mean inspiratory and mean expiratory components (inspiratory-expiratory breath analysis) but these have not been used to compare patients with asthma and those with chronic obstructive pulmonary disease (COPD). Large inspiratory-expiratory variations in Xrs at 5 Hz (DeltaX5) in an individual have been used as a surrogate marker of expiratory flow limitation. METHODS: Whole-breath and inspiratory-expiratory impulse oscillometry was assessed in 34 patients with asthma (49 + or - 3 years; 15 male, forced expiratory volume in 1 s (FEV(1)) 69 + or - 4% predicted), 48 patients with COPD (64 + or - 2 years; 32 male, FEV(1) 59 + or - 3% predicted) and 18 normal subjects (37 + or - 2 years; 8 male). RESULTS: Whole-breath analysis failed to discriminate between patients with asthma and patients with COPD either for all patients or for patients with FEV(1)

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  • P. Paredi

  • M. Goldman

  • A. Alamen

  • P. Ausin

  • O. S Usmani

  • N. B Pride

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