PURPOSE: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral and time domain optical coherence tomography (OCT).
PATIENTS AND METHODS: One hundred and eighty-eight subjects (normal tension glaucoma, n = 80; primary open angle glaucoma, n = 49; healthy controls, n = 59) were included in this study. Peripapillary RNFL thickness was measured by an Optic Disc Cube 200 × 200 scan of the spectral domain Cirrus HD OCT and by a Fast RNFL scan of the time domain Stratus OCT. They were compared using linear regression (R(2)), Bland-Altman plots, weighted Kappa (K(w)) coefficients, and areas under the receiver operating characteristic curve (AROC).
RESULTS: Except for the inferior quadrant, RNFL thickness measurements by Cirrus HD OCT were thinner than Stratus OCT (all p
CONCLUSIONS: Except for the inferior quadrant, the average and quadrants RNFL thickness measured by the Cirrus HD OCT were thinner than the Stratus OCT. Regarding discriminating power for glaucoma detection, the Cirrus HD OCT was better than the Stratus OCT for the superior and inferior quadrant RNFL thicknesses but not for the average RNFL thickness.
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