Comparison of relative forced expiratory volume of one second with dynamic magnetic resonance imaging parameters in healthy subjects and patients with lung cancer

  • Plathow C
  • Fink C
  • Sandner A
 et al. 
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PURPOSE: To assess relative forced expiratory volume in one second (FEV1/vital capacity (VC)) in healthy subjects and patients with a lung tumor using dynamic magnetic resonance imaging (dMRI) parameters. MATERIALS AND METHODS: In 15 healthy volunteers and 31 patients with a non-small-cell lung carcinoma stage I (NSCLC I), diaphragmatic length change (LE1) and craniocaudal (CC) intrathoracic distance change within one second from maximal inspiration (DE1) were divided by total length change (LE(total), DE(total)) as a surrogate of spirometric FEV1/VC using a true fast imaging with steady-state precession (trueFISP) sequence (TE/TR = 1.7/37.3 msec, temporal resolution = 3 images/second). Influence of tumor localization was examined. RESULTS: In healthy volunteers FEV1/VC showed a highly significant correlation with LE1/LE(total) and DE1/DE(total) (r > 0.9, P < 0.01). In stage IB tumor patients, comparing tumor-bearing with the non-tumor-bearing hemithorax, there was a significant difference in tumors of the middle (LE1/LE(total) = 0.63 +/- 0.05 vs. 0.73 +/- 0.04, DE1/DE(total) = 0.66 +/- 0.05 vs. 0.72 +/- 0.04; P < 0.05) and lower (P < 0.05) lung region. Stage IA tumor patients showed no significant differences with regard to healthy subjects. CONCLUSION: dMRI is a simple noninvasive method to locally determine LE1/LE(total) and DE1/DE(total) as a surrogate of FEV1/VC in volunteers and patients. Tumors of the middle and lower lung regions have a significant influence on these MRI parameters.

Author-supplied keywords

  • *Pulmonary Ventilation/physiology
  • Adult
  • Analysis of Variance
  • Body Weights and Measures/methods
  • Carcinoma, Non-Small-Cell Lung/diagnosis/*physiopa
  • Diaphragm/physiology/physiopathology
  • Feasibility Studies
  • Female
  • Forced Expiratory Volume/physiology
  • Humans
  • Lung Neoplasms/diagnosis/*physiopathology
  • Magnetic Resonance Imaging/*methods
  • Male
  • Middle Aged
  • Reference Values
  • Spirometry/methods
  • Thorax/physiology/physiopathology
  • Time Factors

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  • C Plathow

  • C Fink

  • A Sandner

  • S Ley

  • M Puderbach

  • M Eichinger

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