Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons

  • Wei D
  • Mei Y
  • Bagal A
 et al. 
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Abstract

The dendritic arbor of pyramidal neurons is not a monolithic structure. We show here that the excitability of terminal apical dendrites differs from that of the apical trunk. In response to fluorescence-guided focal photolysis of caged glutamate, individual terminal apical dendrites generated cadmium-sensitive all-or-none responses that were subthreshold for somatic action potentials. Calcium transients produced by all-or-none responses were not restricted to the sites of photolysis, but occurred throughout individual distal dendritic compartments, indicating that electrogenesis is mediated primarily by voltage-gated calcium channels. Compartmentalized and binary behavior of parallel-connected terminal dendrites can greatly expand the computational power of a single neuron.

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Authors

  • D. S. Wei

  • Y. A. Mei

  • A. Bagal

  • J. P Y Kao

  • S. M. Thompson

  • C. M. Tang

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