Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.

  • Stover C-K., Pham X-Q., Erwin A-L., Mizoguchi S-D., Warrener P. H
  • Brinkman F-S., Hufnagle W-O., Kowalik D-J., Lagrou M. Garber R-L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L-L., Coulter S-N., Folger K-R., Kas A., Larbig K., Lim R., Smith K., Spencer D., Wong G-K., Wu Z., Paulsen I-T., Reizer J., Sa O
  • 13

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsic resistance to antibiotics and disinfectants. Here we report the complete sequence of P. aeruginosa strain PAO1. At 6.3 million base pairs, this is the largest bacterial genome sequenced, and the sequence provides insights into the basis of the versatility and intrinsic drug resistance of P. aeruginosa. Consistent with its larger genome size and environmental adaptability, P. aeruginosa contains the highest proportion of regulatory genes observed for a bacterial genome and a large number of genes involved in the catabolism, transport and efflux of organic compounds as well as four potential chemotaxis systems. We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Hickey M-J. Stover C-K., Pham X-Q., Erwin A-L., Mizoguchi S-D., Warrener P.

  • Olson M-V. Brinkman F-S., Hufnagle W-O., Kowalik D-J., Lagrou M. Garber R-L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L-L., Coulter S-N., Folger K-R., Kas A., Larbig K., Lim R., Smith K., Spencer D., Wong G-K., Wu Z., Paulsen I-T., Reizer J., Sa

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free