The complex interplay between cholesterol and prostate malignancy

  • Solomon K
  • Freeman M
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Abstract

Research into the role of cholesterol and prostate disease has been ongoing for many years, but our mechanistic and translational understanding is still poor. Recent evidence indicates that cholesterol-lowering drugs reduce the risk of aggressive prostate cancer. This article reviews the literature on the relationship between circulating cholesterol and prostate cancer. The data strongly point to hypercholesterolemia as a risk factor for prostate cancer progression and suggest clinical opportunities for the use of cholesterol-lowering therapies to alter disease course. © 2011 Elsevier Inc.

Author-supplied keywords

  • Castration resistance
  • Cholesterol
  • Prostate cancer
  • Statins
  • Steroidogenesis

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Authors

  • Keith R. Solomon

  • Michael R. Freeman

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