Compliance and immunogenicity of two hepatitis B vaccination schedules in sex workers in Belgium

  • Wouters K
  • Leuridan E
  • Van Herck K
 et al. 
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Abstract

Objectives: To compare the coverage for the third dose and the compliance to two hepatitis B vaccination schedules: 0,1,4 versus 0,1,6 months, in commercial sex workers (CSW) in Belgium; to compare the immunogenicity of the actually administered schedules. Methods: In seven health centres in Belgium, hepatitis B vaccination was offered free of charge to CSW. In a randomised, prospective study a commercialised hepatitis B vaccine (Engerix-B™ 20 mcgr) was offered according to one of both schedules. After complete vaccination, bleeding was performed to assess immunogenicity. Results: Between June 2003 and September 2004, 615 non-immune CSW were enrolled, of whom 52% in the 0,1,4 month schedule (n = 322). Coverage of the third dose was 57% overall, 59% (0,1,4) and 54% (0,1,6), respectively. Age, the health centre and drug use significantly influenced the compliance and the coverage of dose 3, whereas the planned vaccination did not. When comparing the immunogenicity results as a function of the actually administered vaccination schedule, immune responses did not significantly differ between CSW receiving the third dose 4-6 months and those receiving it at least 6 months after the first dose. In total, 19 persons (8%) were not protected after a full vaccination course (anti-HBs

Author-supplied keywords

  • Effectiveness
  • Hepatitis B vaccination
  • Outreach programme
  • Schedule
  • Sex worker

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