Connecting the dots in Huntington's disease with protein interaction networks

  • Giorgini F
  • Muchowski P
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Abstract

Analysis of protein-protein interaction networks is becoming important for inferring the function of uncharacterized proteins. A recent study using this approach has identified new proteins and interactions that might be involved in the pathogenesis of the neurodegenerative disorder Huntington's disease, including a GTPase-activating protein that co-localizes with protein aggregates in Huntington's disease patients.

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Authors

  • Flaviano Giorgini

  • Paul J. Muchowski

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