Connexin expression in electrically coupled postnatal rat brain neurons

  • Venance L
  • Rozov A
  • Blatow M
 et al. 
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Abstract

Electrical coupling by gap junctions is an important form of cell-to-cell communication in early brain development. Whereas glial cells remain electrically coupled at postnatal stages, adult vertebrate neurons were thought to communicate mainly via chemical synapses. There is now accumulating evidence that in certain neuronal cell populations the capacity for electrical signaling by gap junction channels is still present in the adult. Here we identified electrically coupled pairs of neurons between postnatal days 12 and 18 in rat visual cortex, somatosensory cortex, and hippocampus. Notably, coupling was found both between pairs of inhibitory neurons and between inhibitory and excitatory neurons. Molecular analysis by single-cell reverse transcription-PCR revealed a differential expression pattern of connexins in these identified neurons

Author-supplied keywords

  • Adult
  • Animals
  • Article
  • Brain
  • Cell Communication
  • Cells
  • Connexins
  • Gap Junctions
  • Hippocampus
  • In Vitro
  • Microscopy,Interference
  • Neurology
  • Neurons
  • Patch-Clamp Techniques
  • Population
  • Rat
  • Rats
  • Reverse Transcriptase Polymerase Chain Reaction
  • Somatosensory Cortex
  • Support,Non-U.S.Gov't
  • Synapse
  • Synapses
  • Visual Cortex
  • analysis
  • brain development
  • channel
  • channels
  • clinical
  • connexin
  • connexin expression
  • cortex
  • development
  • electrical coupling
  • excitatory
  • expression
  • gap junction
  • genetics
  • glial cells
  • inhibitory
  • neurobiology
  • neuron
  • neuronal
  • pattern
  • physiology
  • postnatal
  • signaling
  • somatosensory
  • visual

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  • PMID: 10944183

Authors

  • L Venance

  • A Rozov

  • M Blatow

  • N Burnashev

  • D Feldmeyer

  • H Monyer

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