The conscious Göttingen minipig as a model for studying rapid pulsatile insulin secretion in vivo

  • Larsen M
  • Elander M
  • Sturis J
 et al. 
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Abstract

AIMS/HYPOTHESIS: Pulsatile secretion is important for insulin action and suitable animal models are important tools for examining the role of impaired pulsatile insulin secretion as a possible link between beta-cell mass, function and morphology and insulin resistance. This study examines the vascular sampling site, insulin kinetics, pulsatility and the response to glucose pulse entrainment to evaluate the Gottingen minipig as a model for studying pulsatile insulin secretion. METHODS: Basal and glucose entrained insulin secretion was examined in normal minipigs and evaluated by autocorrelation, cross correlation and deconvolution. RESULTS: Cross correlation showed a relation between oscillations in insulin concentrations in the portal and jugular vein in anaesthetised animals ( p

Author-supplied keywords

  • Deconvolution
  • In vivo model, insulin action
  • Insulin kinetics
  • Pulsatile insulin secretion

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Authors

  • M. Larsen

  • M. Elander

  • J. Sturis

  • M. Wilken

  • R. Carr

  • B. Rolin

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