The continuing crisis in antibiotic resistance

  • French G
  • 234

    Readers

    Mendeley users who have this article in their library.
  • 135

    Citations

    Citations of this article.

Abstract

The emergence of antibiotic resistance in bacterial pathogens is an inevitable consequence of antibiotic use. Despite repeated warnings, negligent antibiotic use and poor infection-control practice have led to the continuing development of extensive resistance problems worldwide. Multidrug-resistant pathogens are now characterized by their heterogeneity, increasing virulence, resistance even to reserve agents and spread within and between hospitals and the community. Examples are glycopeptide-resistant meticillin-resistant Staphylococcus aureus (MRSA) and enterococci, extended-spectrum β-lactamase- and carbapenemase-producing coliforms, and toxin-hyperproducing Clostridium difficile. Effective national and international programmes of control to combat these problems are urgently needed. The potential for success of such coordinated efforts has been demonstrated by the recent dramatic reductions in MRSA and C. difficile infections in England. © 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Author-supplied keywords

  • Antibiotic resistance
  • Clostridium difficile
  • Enterococci
  • Escherichia coli
  • Infection control
  • Staphylococcus aureus

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free