Contribution of endothelium-derived hyperpolarizing factor to exercise-induced vasodilation in health and hypercholesterolemia

  • Ozkor M
  • Hayek S
  • Rahman A
 et al. 
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The role of endothelium-derived hyperpolarizing factor (EDHF) in either the healthy circulation or in those with hypercholesterolemia is unknown. In healthy and hypercholesterolemic subjects, we measured forearm blood flow (FBF) using strain-gauge plethysmography at rest, during graded handgrip exercise, and after sodium nitroprusside infusion. Measurements were repeated after l-NMMA, tetraethylammonium (TEA), and combined infusions. At rest, l-NMMA infusion reduced FBF in healthy but not hypercholesterolemic subjects. At peak exercise, vasodilation was lower in hypercholesterolemic compared to healthy subjects (274% vs 438% increase in FBF, p=0.017). TEA infusion reduced exercise-induced vasodilation in both healthy and hypercholesterolemic subjects (27%, p

Author-supplied keywords

  • endothelial function
  • endothelium-derived hyperpolarizing factor
  • exercise
  • hypercholesterolemia
  • nitric oxide
  • vasodilation

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  • Muhiddin A. Ozkor

  • Ayaz M. Rahman

  • Jonathan R. Murrow

  • Nino Kavtaradze

  • Ji Lin

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