Contributions of B cells to lupus pathogenesis

  • Sang A
  • Zheng Y
  • Morel L
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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.

Author-supplied keywords

  • Autoimmunity
  • B cells
  • Lupus

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Authors

  • Allison SangAnschutz Medical Campus-University of Colorado

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  • Ying Yi Zheng

  • Laurence Morel

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