Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells

  • Van Pinxteren L
  • Cassidy J
  • Smedegaard B
 et al. 
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Abstract

It is estimated that one-third of the world's population is infected with Mycobacterium tuberculosis, but that only 10% of infected people break down with the disease. In the remaining 90% the infection remains clinically latent. In the present study, the immune mechanisms controlling the latent phase of tuberculosis infection were evaluated in a mouse model of latency and reactivation. Mice aerosol-infected with M. tuberculosis were treated with anti-mycobacterial drugs resulting in very low, stable bacterial numbers (

Author-supplied keywords

  • CD8 T cell
  • Latency
  • Tuberculosis

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Authors

  • Laurens A H Van Pinxteren

  • Joseph P. Cassidy

  • Birgitte H C Smedegaard

  • Else M. Agger

  • Peter Andersen

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