Control of nanostructures in PVA, PVA/chitosan blends and PCL through electrospinning

  • Sajeev U
  • Anand K
  • Menon D
 et al. 
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Abstract

Aqueous solutions of polyvinyl alcohol (PVA) were electrospun and its characteristics were studied as a function of applied potential, tip-target distance and solution flow rate. Solutions of PVA and chitosan were homogeneously mixed and electrospun to result in blend nanofibres and their properties were investi-gated. Conditions were revealed under which multiscale bi-modal fibres could be electrospun in a single step, producing structures that have potential applications in tissue engineering. Electrospun fibres having a bimodal size distribution of poly(caprolactone) (PCL) were also fabricated using a modified electrospinning setup. Nanofibrous microporous PVA scaffolds were fabricated using a cryogenic grinding method with subsequent compaction. Such multiscale porous structures would offer ideal matrices for tissue engineering applications.

Author-supplied keywords

  • Electrospinning
  • Multiscale fibres
  • Nanofibres
  • Scaffolds
  • Tissue engineering

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Authors

  • U. S. Sajeev

  • K. Anoop Anand

  • Deepthy Menon

  • Shanti Nair

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