Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia

  • Gadelha A
  • Vendramini A
  • Yonamine C
 et al. 
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Abstract

In schizophrenia (SCZ), higher angiotensin I-converting enzyme (ACE) levels have been reported in patient’s blood and cerebrospinal fluid (CSF). Hereby, we propose to explore whether the ACE activity levels are associated to cognitive performance in SCZ. Seventy-two patients with SCZ or schizoaffective disorder diagnosis, and 69 healthy controls (HCs) underwent a cognitive battery with parallel collection of peripheral blood samples to measure ACE activity. Significant higher ACE activity levels were confirmed in the plasma of SCZ patients compared with HCs (Student’s t=−5.216; P

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