Conversion of mouse mammary tumor virus to a lymphomagenic virus.

  • Bhadra S
  • Lozano M
  • Dudley J
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Abstract

Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of transcriptional repression through deletion of negative regulatory elements (NREs) or by suppression of NRE activity after appropriate positioning of the enhancer.

Author-supplied keywords

  • Animals
  • Cell Line
  • Enhancer Elements
  • Experimental
  • Experimental: virology
  • Genes
  • Genetic
  • Humans
  • Inbred BALB C
  • Jurkat Cells
  • Lymphoma
  • Mammary Neoplasms
  • Mammary Tumor Virus
  • Mice
  • Mouse
  • Mouse: genetics
  • Mouse: pathogenicity
  • Proviruses
  • Proviruses: genetics
  • Proviruses: pathogenicity
  • Regulator
  • Retroviridae Infections
  • Retroviridae Infections: virology
  • T-Cell
  • T-Cell: virology
  • T-Lymphocytes
  • T-Lymphocytes: virology
  • Terminal Repeat Sequences
  • Transcription
  • Transfection
  • Tumor Virus Infections
  • Tumor Virus Infections: virology

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Authors

  • Sanchita Bhadra

  • Mary M Lozano

  • Jaquelin P Dudley

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