Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of transcriptional repression through deletion of negative regulatory elements (NREs) or by suppression of NRE activity after appropriate positioning of the enhancer.
CITATION STYLE
Bhadra, S., Lozano, M. M., & Dudley, J. P. (2005). Conversion of Mouse Mammary Tumor Virus to a Lymphomagenic Virus. Journal of Virology, 79(19), 12592–12596. https://doi.org/10.1128/jvi.79.19.12592-12596.2005
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