Copper catalyzed atom transfer radical addition (ATRA) and cyclization (ATRC) reactions in the presence of reducing agents

  • Eckenhoff W
  • Pintauer T
  • 31


    Mendeley users who have this article in their library.
  • 104


    Citations of this article.


This article reports on recent advances in the area of catalyst regeneration in copper mediated atom transfer radical addition (ATRA) and cyclization (ATRC) reactions using free-radical diazo initiators as reducing agents. The role of reducing agent in both processes is to continuously regenerate the activator (copper(I) complex) from the deactivator (copper(II) complex). As a result, single addition adducts in ATRA and ATRC reactions can be synthesized using very low concentrations of copper catalysts (5–100 pm). Previously, efficient catalysis for both processes required as much as several thousands ppm of copper. It is envisioned that the recent developments in this area could have important industrial implications on the synthesis of small organic molecules, natural products and pharmaceutical drugs.

Author-supplied keywords

  • ATRA
  • ATRC
  • Catalysis
  • Copper
  • Reducing agents

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • William T. Eckenhoff

  • Tomislav Pintauer

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free