Copper(I) carboxylate catalyzed C-N coupling of 2-amino pyrimidines with aryl halides to selectively generate secondary and tertiary amines

  • Zhang Y
  • Quan Z
  • Gong H
 et al. 
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(2-Chlorobenzoyloxy)copper(I) exhibited high activity towards the challenging amination of 2-amino pyrimidines with aryl halides. Herein, secondary and tertiary amines were selectively produced by using potassium phosphate and sodium-t-butoxide. Potassium phosphate favored the formation of secondary amines, whereas tertiary amines were favored when sodium-t-butoxide was used.

Author-supplied keywords

  • 2-Aminopyrimidines
  • Amination
  • Cu(I)-catalyst
  • Secondary amines
  • Tertiary amines

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  • Yue Zhang

  • Zheng Jun Quan

  • Hai Peng Gong

  • Yu Xia Da

  • Zhang Zhang

  • Xi Cun Wang

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