Corpus callosum atrophy is a possible indicator of region- and cell type-specific neuronal degeneration in Alzheimer disease: A magnetic resonance imaging analysis

  • Hampel H
  • Teipel S
  • Alexander G
 et al. 
  • 59


    Mendeley users who have this article in their library.
  • 160


    Citations of this article.


Background: Pathological studies in Alzheimer dis- ease indicate the specific loss of layer III and V large py- ramidal neurons in association cortex. These neurons give rise to long corticocortical connections within and be- tween the cerebral hemispheres. Objective:To evaluate the corpus callosum as an in vivo marker for cortical neuronal loss. Method: Using a new imaging technique, we mea- sured region-specific corpus callosum atrophy in patients with Alzheimer disease and correlated the changes with neuropsychological functioning. Total cross-sectional area of the corpus callosum and areas of 5 callosal subregions were measured on mid- sagittal magnetic resonance imaging scans of 14 patients with Alzheimer disease (mean age, 64.4 years; Mini-Mental State Examination score, 11.4) and 22 healthy age- and sex-matched control subjects (mean age, 66.6 years; Mini-Mental State Examination score, 29.8). All subjects had minimal white matter changes. Results: The total callosal area was significantly re- duced in the patients with Alzheimer disease, with the greatest changes in the rostrum and splenium and rela- tive sparing of the callosal body. Regional callosal atro- phy correlated significantly with cognitive impairment in the patients with Alzheimer disease, but not with age or the white matter hyperintensities score. Conclusions: Callosal atrophy in patients with Alzhei- mer disease with only minimal white matter changes may indicate loss of callosal efferent neurons in correspond- ing regions of the cortex. Because these neurons are a sub- set of corticocortical projecting neurons, region-specific callosal atrophymayserve as a marker of progressive neo- cortical disconnection in Alzheimer disease.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free