Correlation of immune cell activities and ??-endorphin release in breast carcinoma patients treated with galactose-specific lectin standardized mistletoe extract

  • Heiny B
  • Albrecht V
  • Beuth J
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A prospectively randomized clinical study was performed with breast carcinoma patients to determine the correlation of defined parameters of the cellular immunity and beta-endorphin plasma levels after mistletoe lectin (ML-1) standardized therapy. The subcutaneous administration of optimal ML-1 dosages (0.5-1.0 ng ML-1/kg body weight; twice a week) induced an increased beta-endorphin plasma level, enhanced activity of peripheral blood natural killer (NK-)cells and T-lymphocytes (expression of CD-25/interleukin-2 receptors and HLA/DR-antigens). Statistical analysis of the data (Spearman correlation) revealed a significant correlation between NK- and T-cell activity and beta-endorphin plasma level. Thus, an obvious correlation between immune system and the neuroendocrine system may be anticipated which might gain therapeutical relevance.

Author-supplied keywords

  • ??-endorphin plasma level
  • Breast carcinoma patients
  • Correlation
  • Immune cell activity
  • Mistletoe lectin-1

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  • Bernd Michael Heiny

  • Valentina Albrecht

  • Josef Beuth

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