Cortical excitability varies upon ictal onset patterns in neocortical epilepsy: A cortico-cortical evoked potential study

  • Enatsu R
  • Piao Z
  • O'Connor T
 et al. 
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Abstract

Objective: To better understand pathological neuronal excitation in epilepsy by comparing cortico-cortical evoked potential (CCEP) responses in regions with different ictal onset patterns: focal paroxysmal fast (PF) and repetitive spiking (RS). Methods: Fourteen patients undergoing invasive monitoring (six patients with PF and eight with RS) were studied with CCEPs. A repetitive 1Hz bipolar electrical stimulus was applied to both the ictal onset region (iCCEP) and to a control region (nCCEP) and CCEPs were recorded from the surrounding electrodes. The two groups were compared by subtracting the amplitude of nCCEP from that of iCCEP (CCEPictal-control) at each stimulus intensity, and then normalizing the amplitudes of iCCEP at maximum stimulus intensity by dividing by nCCEP (CCEPictal/control). Results: The CCEP response to stimulation in the ictal onset region was significantly larger than to control stimulation for both ictal patterns (paroxysmal fast: P=0.02, repetitive spiking: P

Author-supplied keywords

  • Cortical stimulation
  • Electrocorticography
  • Epilepsy
  • Evoked potential
  • Ictal onset

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