Counterfeit or substandard antimicrobial drugs: A review of the scientific evidence

  • T. K
  • I. K
  • P.I. R
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Abstract

There is growing universal concern regarding counterfeit medications. In particular, counterfeit antimicrobial drugs are a threat to public health with many devastating consequences for patients; increased mortality and morbidity and emergence of drug resistance. In addition, physicians treating these patients lose their confidence in the medications used and report high levels of bacterial resistance. The problem with fake and suboptimal medications got worse with the advent of the World Wide Web; a significant proportion of medications that are sold through Internet pharmacies is counterfeit. Various initiatives of the WHO (the International Medical Products Anti-Counterfeiting Taskforce) are hopefully going to tackle this very important public health issue. In this article, we review the available evidence in peer-reviewed articles and World Wide Web information resources regarding the issue of counterfeit antimicrobials. © The Author 2007.

Author-supplied keywords

  • *antiinfective agent/an [Drug Analysis]
  • *antiinfective agent/pr [Pharmaceutics]
  • *drug quality
  • Internet
  • amoxicillin/an [Drug Analysis]
  • ampicillin/an [Drug Analysis]
  • ampicillin/pr [Pharmaceutics]
  • antibiotic resistance
  • antimalarial agent/an [Drug Analysis]
  • antimalarial agent/pr [Pharmaceutics]
  • antiparasitic agent/an [Drug Analysis]
  • antivirus agent/an [Drug Analysis]
  • azithromycin/an [Drug Analysis]
  • cefalexin/an [Drug Analysis]
  • cefazolin/an [Drug Analysis]
  • cefotaxime/an [Drug Analysis]
  • cefradine/an [Drug Analysis]
  • ceftazidime/an [Drug Analysis]
  • ceftriaxone/an [Drug Analysis]
  • cephalosporin derivative/an [Drug Analysis]
  • chlortetracycline/an [Drug Analysis]
  • ciprofloxacin/an [Drug Analysis]
  • clarithromycin/an [Drug Analysis]
  • cotrimoxazole/an [Drug Analysis]
  • doxycycline/an [Drug Analysis]
  • drug bioavailability
  • drug formulation
  • drug stability
  • erythromycin/an [Drug Analysis]
  • gentamicin/an [Drug Analysis]
  • good manufacturing practice
  • human
  • macrolide/an [Drug Analysis]
  • metronidazole/an [Drug Analysis]
  • morbidity
  • mortality
  • nalidixic acid/an [Drug Analysis]
  • neomycin/an [Drug Analysis]
  • neomycin/pr [Pharmaceutics]
  • ofloxacin/an [Drug Analysis]
  • peer review
  • pharmacy
  • prevalence
  • public health
  • quantitative analysis
  • review
  • roxithromycin/an [Drug Analysis]
  • tetracycline/an [Drug Analysis]
  • tuberculostatic agent/an [Drug Analysis]
  • unindexed drug
  • world health organization

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Authors

  • Kelesidis T.

  • Kelesidis I.

  • Rafailidis P.I.

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