Covalent interactions are not required to permit or stabilize the non- covalent association of hepatitis C virus glycoproteins E1 and E2

  • Patel J
  • Patel A
  • McLauchlan J
  • 4

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Abstract

Hepatitis C virus (HCV) encodes two glycoproteins, E1 and E2, which are thought to locate to the envelope of virus particles. These proteins form two complexes in tissue culture systems, a high molecular mass aggregate that contains intermolecular covalent bonds and a native complex in which E1 and E2 associate by non-covalent interactions. The contribution of either complex to the structures of the proteins on virus particles is not known. Using dithiothreitol to reduce i

Author-supplied keywords

  • Hepatitis C
  • Hepatitis C-Like Viruses
  • Human
  • Mutation
  • Protein Binding
  • Protein Conformation
  • Proteins
  • Viral Envelope Proteins
  • chemistry
  • genetics
  • metabolism
  • virology

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Authors

  • J Patel

  • A H Patel

  • J McLauchlan

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