At the crossroads of growth control; making ribosomal RNA

  • Moss T
  • 79


    Mendeley users who have this article in their library.
  • 117


    Citations of this article.


Although the mechanisms of cell cycle control are well established, the factors controlling cell growth and target size are still poorly understood. Much evidence suggests that ribosome biogenesis, and in particular the synthesis of the rRNAs, plays a central role not only in permitting growth, but also in regulating it. In the past few years we have begun to penetrate the network linking rRNA gene transcription to growth.

Author-supplied keywords

  • CE
  • CF
  • Core factor
  • Core promoter element
  • HDAC
  • Histone deacetylase
  • NORs
  • Nucleolar organiser regions
  • PolI
  • RENT
  • RNA polymerase I
  • Regulator of nucleolar silencing and telophase exit
  • Ribosomal RNA
  • SL1
  • Selectivity factor 1
  • TATA-box binding protein
  • TBP
  • rRNA

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Tom Moss

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free