Crosstalk between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development

  • Yoo A
  • Bais C
  • Greenwald I
  • 130

    Readers

    Mendeley users who have this article in their library.
  • 179

    Citations

    Citations of this article.

Abstract

The Caenorhabditis elegans vulva is an important paradigm for cell-cell interactions in animal development. The fates of six vulval precursor cells are patterned through the action of the epidermal growth factor receptor-mitogen-activated protein kinase (EGFR-MAPK) inductive signaling pathway, which specifies the 1 degrees fate, and the LIN-12/Notch lateral signaling pathway, which specifies the 2 degrees fate. Here, we provide evidence that the inductive signal is spatially graded and initially activates the EGFR-MAPK pathway in the prospective 2 degrees cells. Subsequently, this effect is counteracted by the expression of multiple new negative regulators of the EGFR-MAPK pathway, under direct transcriptional control of the LIN-12-mediated lateral signal.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Andrew S. Yoo

  • Carlos Bais

  • Iva Greenwald

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free