Crystal structure of thioflavin-T and its binding to amyloid fibrils: Insights at the molecular level

  • Rodríguez-Rodríguez C
  • Rimola A
  • Rodríguez-Santiago L
 et al. 
  • 55

    Readers

    Mendeley users who have this article in their library.
  • 38

    Citations

    Citations of this article.

Abstract

Combining X-ray data on thioflavin-T and theoretical calculations on its binding to a peptide model for Abeta(1-42) fibrils gives evidence of main stabilizing interactions, which influence the dihedral angle between the two moieties of thioflavin-T and thereby its fluorescence properties; these results shed new light on possible strategies for the design of dyes to bind amyloid fibrils more specifically.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free