Curing epilepsy: Progress and future directions

  • M.P. J
  • G.G. L
  • A. B
 et al. 
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Abstract

During the past decade, substantial progress has been made in delineating clinical features of the epilepsies and the basic mechanisms responsible for these disorders. Eleven human epilepsy genes have been identified and many more are now known from animal models. Candidate targets for cures are now based upon newly identified cellular and molecular mechanisms that underlie epileptogenesis. However, epilepsy is increasingly recognized as a group of heterogeneous syndromes characterized by other conditions that co-exist with seizures. Cognitive, emotional and behavioral co-morbidities are common and offer fruitful areas for study. These advances in understanding mechanisms are being matched by the rapid development of new diagnostic methods and therapeutic approaches. This article reviews these areas of progress and suggests specific goals that once accomplished promise to lead to cures for epilepsy. © 2009 Elsevier Inc.

Author-supplied keywords

  • Stevens Johnson syndrome
  • anticonvulsive agent
  • behavior disorder
  • brain electrophysiology
  • carbamazepine
  • cognitive defect
  • comorbidity
  • depression
  • epigenetics
  • epilepsy
  • epileptic state
  • epileptogenesis
  • galanin
  • gene mutation
  • genetic risk
  • genetic susceptibility
  • genotype environment interaction
  • glial cell line derived neurotrophic factor
  • human
  • long term potentiation
  • mental disease
  • nerve cell plasticity
  • nervousness
  • neuroimaging
  • neuropeptide Y
  • neurotransmission
  • nonhuman
  • parvovirus vector
  • pharmacogenetics
  • prenatal drug exposure
  • rapamycin
  • review
  • side effect
  • skin disease
  • stem cell transplantation
  • synaptogenesis
  • topiramate
  • toxic epidermal necrolysis
  • tuberous sclerosis
  • valproic acid
  • vigabatrin
  • viral gene therapy

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Authors

  • Jacobs M.P.

  • Leblanc G.G.

  • Brooks-Kayal A.

  • Jensen F.E.

  • Lowenstein D.H.

  • Noebels J.L.

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